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Du tits mod action, mupiocin dos not dmonstat coss sistanc with oth classs antimicobial agnts.
In addition tadvs actions potd om clinical tials, th ollowing actions hav bn idntiid duing postmakting us BACTOBAN ointmnt. Bcaus thy a potd voluntaily om a population unknown siz, stimats quncy cannot b mad. Ths actions hav bn chosn inclusion du ta combination thi siousnss, quncy poting, potntial causal lationship tBACTOBAN ointmnt.
Whn mupiocin sistanc occus, it sults om th poduction a modiid isolucyl-tNA synthtas, th acquisition o, by gntic tans, a plasmid mdiating a nw isolucyl-tNA synthtas. High-lvl plasmid-mdiatd sistanc (MIC ? 512 mcg/mL) has bn potd in incasing numbs isolats S. auus and with high quncy in coagulas-ngativ staphylococci. Mupiocin sistanc occus with gat quncy in mthicillin-sistant than mthicillin-suscptibl staphylococci.
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