The fda first approved lamictal in 1994 as an anti-seizure medication.

Information about Lamictal.

In dogslamotrigine is extensively metabolized to a 2-N-methyl metaboliteThis metabolite causes dose-dependent prolongation of the PR intervalwidening of the QRS complexandat higher dosescomplete AV conduction blockSimilar cardiovascular effects are not anticipated in humans because only trace amounts of the 2-N-methyl metabolitea in Healthy Volunteers and Adult Subjects with Epilepsy.

Dosage adjustments may be necessary for women receiving estrogen-containing oral contraceptive preparationssee DOSAGE AND ADMINISTRATION

AEDsincluding LAMICTALincrease the risk of suicidal thoughts or behavior in patients taking these drugs for any indicationPatients treated with any AED for any indication should be monitored for the emergence or worsening of depressionsuicidal thoughts or behaviorand/or any unusual changes in mood or behavior.

Inform patients who intend to breastfeed that LAMICTAL is present in breast milk and advise them to monitor their child for potential adverse effects of this drugDiscuss the benefits and risks of continuing breastfeeding.

If your medication comes in a blisterpackcheck the blisterpack before you take your first doseDo not use any of the medication from the pack if any of the blisters are tornbrokenor do not contain tablets.

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