Surprisingly, it is seen that effervescent forms formulated with the formulation comprising 5-40 of cefixime, 1-20 of the mixture of potasium clavulanate humidity absorbing agent 1 1 , 25-75 of effervescent couple and 1- 15 of at least one pharmaceutically acceptable excipient are quite stable and form a homogeneous solution by completely dissolving in water.
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Gonorrhea Chlamydia Zika virus Genital herpes Hepatitis B Hepatitis C Pubic lice Scabies Genital warts.
Gastric lavage may be indicatedotherwiseno specific antidote existsCefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysisAdverse reactions in small numbers of healthy adult volunteers receiving single doses up to 2 g of cefixime did not differ from the profile seen in patients treated at the recommended doses.
Symptoms of overdose include blood in the urinediarrheanauseaupper abdominal painand vomiting.
Combining cefixime with aminoglycosidesfor exampletobramycinTobradexproduces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney
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in another aspect, the present invention is related to the process for the preparation of pharmaceutical combinations comprising cefixime as active agent and pharmaceutically acceptable excipients.