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A syndrome consisting of potentially irreversibleinvoluntarydyskinetic movements may develop in patients treated with antipsychotic drugssee ADVERSE REACTIONSAlthough the prevalence of the syndrome appears to be highest among the elderlyespecially elderly womenit is impossible to rely upon prevalence estimates to predictat the inception of antipsychotic treatmentwhich patients are likely to develop the syndromeWhether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown.
Since there is no specific antidotetreatment is primarily supportiveA patent airway must be established by use of an oropharyngeal airway or endotracheal tube orin prolonged cases of comaby tracheostomyRespiratory depression may be counteracted by artificial respiration and mechanical respiratorsHypotension and circulatory collapse may be counteracted by use of intravenous fluidsplasmaor concentrated albuminand vasopressor agents such as metaraminolphenylephrine and norepinephrineEpinephrine should not be usedIn case of severe extrapyramidal reactionsantiparkinson medication should be administeredECG and vital signs should be monitored especially for signs of Q-T prolongation or dysrhythmias and monitoring should continue until the ECG is normalSevere arrhythmias should be treated with appropriate anti-arrhythmic measures.
In rare caseshaloperidol may increase your level of a certain chemical made by the bodyprolactinFor femalesthis increase in prolactin may result in unwanted breast milkmissed/stopped periodsor difficulty becoming pregnantFor malesit may result in decreased sexual abilityinability to produce spermor enlarged breastsIf you develop any of these symptomstell your doctor right away.
Haldol also may cause abnormal heart beatssudden deathseizuresdecreases in red and white blood cellsand withdrawal symptoms.
Given these considerationsantipsychotic drugs should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesiaChronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that1is known to respond to antipsychotic drugsand2for whom alternativeequally effectivebut potentially less harmful treatments are not available or appropriateIn patients who do require chronic treatmentthe smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be soughtThe need for continued treatment should be reassessed periodically.
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