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Information about Indinavir.
There may be other combinations of protease inhibitors that can be prescribed together with indinavirDiscuss these possibilities with your doctor.
Midazolam is extensively metabolized by CYP3A4Co-administration with CRIXIVAN with or without ritonavir may cause a large increase in the concentration of this benzodiazepineNo drug interaction study has been performed for the co-administration of CRIXIVAN with benzodiazepinesBased on data from other CYP3A4 inhibitorsplasma concentrations of midazolam are expected to be significantly higher when midazolam is given orallyTherefore CRIXIVAN should not be co-administered with orally administered midazolamsee CONTRAINDICATIONSwhereas caution should be used with coadministration of CRIXIVAN and parenteral midazolamData from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3-4 fold increase in midazolam plasma levelsIf CRIXIVAN with or without ritonavir is co-administered with parenteral midazolamit should be done in a setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedationDosage reduction for midazolam should be consideredespecially if more than a single dose of midazolam is administered.
Patients should be advised to avoid doing things that can spread HIV-1 infection to others.
CRIXIVAN Capsules are sensitive to moisturePatients should be informed that CRIXIVAN should be stored and used in the original container and the desiccant should remain in the bottle.
The following drugs interact or have the potential to interact with indinavirThese lists are not exhaustive.
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