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PRECAUTIONS DEPO-MEDROL Sterile Aqueous Suspension exerts an inhibitory influence on the mechanisms and the tissue changes associated with inflammationVascular permeability is decreasedexudation diminishedand migration of the inflammatory cells markedly inhibitedIn additionsystemic manifestations such as fever and signs of toxemia may also be suppressedWhile certain aspects of this alteration of the inflammatory reaction may be beneficialthe suppression of inflammation may mask the signs of infection and tend to facilitate spread of microorganismsHenceall patients receiving this drug should be watched for evidence of intercurrent infectionShould infection occurit must be brought under control by the use of appropriate antibacterial measuresor administration of this preparation should be discontinuedHoweverin infections characterized by overwhelming toxicitymethylprednisolone acetate therapy in conjunction with appropriate antibacterial therapy is effective in reducing mortality and morbidityWithout conjoint use of an antibiotic to which the invader-organism is sensitiveinjudicious use of the adrenal hormones in animals with infections can be hazardousAs with other corticoidscontinued or prolonged use is discouraged.
The most commonly occurring side effects have included fluid retentionalteration in glucose toleranceincreased blood pressurebehavioral and mood changesincreased appetiteand weight gainthe incidence generally correlates with dosagetiming of administrationand duration of treatmentRef]
Methylprednisolone acetatea slightly soluble ester of methylprednisoloneis capable of producing a more prolonged local anti-inflammatory effect than equimolar doses of hydrocortisone acetateFollowing intrasynovial injectionrelief from pain may be experienced within 12 to 24 hoursThe duration of relief variesbut averages three to four weekswith a range of one to five or more weeksInjections of methylprednisolone acetate have been well toleratedIntrasynovialintra-articularinjections may occasionally result in an increased localized inflammatory response.
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