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Data from a XENICAL and cyclosporine drug interaction study indicate a reduction in cyclosporine plasma levels when XENICAL was coadministered with cyclosporineThereforeXENICAL and cyclosporine should not be simultaneously coadministeredTo reduce the chance of a drug-drug interactioncyclosporine should be taken at least 3 hours before or after XENICAL in patients taking both drugsIn additionin those patients whose cyclosporine levels are being measuredmore frequent monitoring should be considered.

A pharmacokinetic studywhere amiodarone was orally administered during orlistat treatmentdemonstrated a reduction in exposure to amiodarone and its metabolitedesethylamiodaronesee CLINICAL PHARMOCOLOGYA reduced therapeutic effect of amiodarone is possibleThe effect of commencing orlistat treatment in patients on stable amiodarone therapy has not been studied.

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never take two doses of orlistat at the same time.