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The Women’s Health InitiativeWHIestrogen-alone substudy reported increased risks of stroke and deep vein thrombosisDVTin postmenopausal women with daily oral conjugated estrogensCEaloneThe WHI estrogen-plus-progestin substudy reported increased risks of DVTpulmonary embolismstrokeand myocardial infarction in postmenopausal women with daily oral CE combined with medroxyprogesterone acetateMPAIn the absence of comparable datathese risks should be assumed to be similar for other dosage forms of estrogens.
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ESTRACE should not be used inwomen with undiagnosed abnormal genital bleedingknownsuspected or history of breast cancerknown or suspected estrogen-dependent neoplasiaactive deep vein thrombosispulmonary embolism or a history of these conditionsactive arterial thromboembolic diseasefor examplestrokemyocardial infarctionor a history of these conditionsknown anaphylactic reaction or angioedema to ESTRACEliver dysfunction or diseasethrombophilic disordersknown or suspected pregnancy.
Most prospective studies of efficacy for this indication have been carried out in white menopausal womenwithout stratification by other risk factorsand tend to show a universally salutary effect on bone.
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