Qureshi et al 31 performed the largest study to date comparing dexamethasone with prednisone.

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The diurnal rhythm of the HPA axis is lost in Cushing’s diseasea syndrome of adrenocortical hyperfunction characterized by obesity with centripetal fat distributionthinning of the skin with easy bruisabilitymuscle wasting with weaknesshypertensionlatent diabetesosteoporosiselectrolyte imbalanceetcThe same clinical findings of hyperadrenocorticism may be noted during long-term pharmacologic dose corticoid therapy administered in conventional daily divided dosesIt would appearthenthat a disturbance in the diurnal cycle with maintenance of elevated corticoid values during the night may play a significant role in the development of undesirable corticoid effectsEscape from these constantly elevated plasma levels for even short periods of time may be instrumental in protecting against undesirable pharmacologic effects.
Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapytrichinosis with neurologic or myocardial involvement.
Your age the condition being treated the severity of your condition other medical conditions you have how you react to the first dose.
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