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When NSAIDs were administered with aspirinthe protein binding of NSAIDs were reducedalthough the clearance of free NSAID was not alteredThe clinical significance of this interaction is not knownSee Table 3 for clinically significant drug interactions of NSAIDs with aspirinsee DRUG INTERACTIONS
Advise patients to stop CELEBREX immediately if they develop any type of rash and to contact their healthcare provider as soon as possiblesee WARNINGS AND PRECAUTIONS
Severe skin reactionfeversore throatswelling in your face or tongueburning in your eyesskin pain followed by a red or purple skin rash that spreadsespecially in the face or upper bodyand causes blistering and peeling.
Monitor blood pressureBPduring the initiation of NSAID treatment and throughout the course of therapy.
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