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Th isk myopathy duing tatmnt with statins is incasd with concunt administation ibic acid divativs, lipid-modiying doss niacin, cyclospoin stong CYP3A4 inhibitos (.g., claithomycin, HIV potas inhibitos and itaconazol).
In animal modls, atovastatin lows plasma cholstol and lipopotin lvls by inhibiting HMG-CoA ductas and cholstol synthsis in th liv and by incasing th numb hpatic LDL cptos on th cll suac tnhanc uptak and catabolism LDL; atovastatin alsducs LDL poduction and th numb LDL paticls.
Ztimib: Th us ztimib alon is associatd with muscl-latd vnts, including habdomyolysis. Th isk ths vnts may, tho, b incasd with concomitant us ztimib and ATOLIP CV . Appopiat clinical monitoing ths patints is commndd.
In adult patints without clinically vidnt CHD, but with multipl isk actos CHD such as ag, smoking, hyptnsion, low HDL-C, a amily histoy aly CHD, atovastatin is indicatd to.
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reduce the risk of myocardial infarction reduce the risk of stroke reduce the risk for revascularization procedures and angina in patients with type 2 diabetes, without clinically evident chd, but with multiple risk factors for chd present such as retinopathy, albuminuria, smoking, or hypertension, atorlip is used to reduce the risk of myocardial infarction and reduce the risk of stroke.