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Your healthcare provider may need to check you more carefully if you have certain conditionssuch as asthmawheezingepilepsyseizuresmigraineendometriosislupusproblems with your heartliverthyroidkidneysor have high calcium levels in your blood.
Check with your doctor immediately if any of the following side effects occur while taking estradiol:
Long term continuous administration of natural and synthetic estrogens in certain animal species increases the frequency of carcinomas of the breastuteruscervixvaginatestisand liver.
Most prospective studies of efficacy for this indication have been carried out in white menopausal womenwithout stratification by other risk factorsand tend to show a universally salutary effect on bone.
There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogensAdding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasiawhich may be a precursor to endometrial cancerAdequate diagnostic measuresincluding directed or random endometrial sampling when indicatedshould be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding.
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