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Chromosomal abnormalitieswhich disappear with timehave been demonstrated in lymphocytes from the offspring of patients treated with ImuranExcept in extremely rare casesno overt physical evidence of abnormality has been observed in the offspring of patients treated with ImuranAzathioprine and long-wave ultraviolet light have been shown to have a synergistic clastogenic effect in patients treated with azathioprine for a range of disorders.
Imuran is an immune system-suppressing drugThat means that it can theoretically halt the attack of the immune system on your nerves if you have multiple sclerosisThe drug can be used to slow the progression of MS in people who are not responding well to other treatments.
In cases of multiple sclerosisImuran is generally taken orallyin the form of tablets.
Patients receiving immunosuppressive therapyincluding azathioprine are at an increased risk of developing lymphoproliferative disorders and other malignanciesnotably skin cancersmelanoma and non-melanomasarcomasKaposi’s and non-Kaposi’sand uterine cervical cancer in situThe increased risk appears to be related to the degree and duration of immunosuppressionIt has been reported that discontinuation of immunosuppression may provide partial regression of the lymphoproliferative disorder.
There has been a case report suggesting that haematological abnormalities may develop due to the concomitant administration of Imuran and captopril.
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