1 however, most of the commentary to date has focused on the most familiar indication for colchicine, the treatment of acute gout.
Information about Colchicine.
There were no studies of the effects of colchicine capsules on fertilityHoweverpublished nonclinical studies have demonstrated that colchicine-induced disruption of microtubule formation affects meiosis and mitosisPublished reproductive studies with colchicine reported abnormal sperm morphology and reduced sperm counts in malesand interference with sperm penetrationsecond meiotic divisionand normal cleavage in females.
There is no difference between men and women in the pharmacokinetic disposition of colchicine.
Ask your healthcare provider or pharmacist if you are not sure if you take any of the medicines listed aboveThis is not a complete list of all the medicines that can affect colchicine capsules.
The first stage of acute colchicine toxicity typically begins within 24 hours of ingestion and includes gastrointestinal symptoms such as abdominal painnauseavomitingdiarrheaand significant fluid lossleading to volume depletionPeripheral leukocytosis may also be seenLife-threatening complications occur during the second stagewhich occurs 24 to 72 hours after drug administrationattributed to multi-organ failure and its associated consequencesDeath usually results from respiratory depression and cardiovascular collapseIf the patient survivesrecovery of multi-organ injury may be accompanied by rebound leukocytosis and alopecia starting about 1 week after the initial ingestionTreatment of colchicine overdose should begin with gastric lavage and measures to prevent shockOtherwisetreatment is symptomatic and supportiveNo specific antidote is knownColchicine is not effectively removed by hemodialysisSee Pharmacokinetics
Cholesterol drugssuch as atorvastatinfluvastatinlovastatinpravastatinsimvastatinfibratesor gemfibrozilIncreased side effects can include serious muscle damageYour doctor may reduce your dosage of colchicine to avoid thisDigoxinan antiarrhythmic drugIncreased side effects can include serious muscle damageYour doctor may reduce your dosage of colchicine to avoid thisHeart drugssuch as verapamil or diltiazemIncreased side effects can include stomach painconstipationdiarrheanauseaor vomitingYour doctor may reduce your dosage of colchicine to avoid these problems.
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