Patients in whom chloroquine or hydroxychloroquine have failed to prevent or cure clinical malaria or parasitemia, or patients who acquired malaria in a geographic area where chloroquine resistance is known to occur should be treated with another form of antimalarial therapy see indications and usage malaria and warnings .
Information about Chloroquine.
Complete blood cell counts should be made periodically if patients are given prolonged therapyIf any severe blood disorder appears which is not attributable to the disease under treatmentdiscontinuance of the drug should be considered.
Retinopathy/maculopathyas well as macular degeneration have been reportedsee ADVERSE REACTIONSand irreversible retinal damage has been observed in some patients who had received long-term or high-dosage 4-aminoquinoline therapyRetinopathy has been reported to be dose relatedRisk factors for the development of retinopathy include ageduration of treatmenthigh daily and/or cumulated doses.
Belly painStomach crampsNot hungryUpset stomach or throwing upHeadacheLoose stoolsdiarrheaChange in color of skinChange in color of hairHair loss.
Chemicallyit is 7-chloro-44diethylamino1-methylbutyl]aminoquinoline phosphate1:2and has the following structural formula:
ARALEN is indicated for the suppressive treatment and for acute attacks of malaria due to PvivaxP.malariaePovaleand susceptible strains of PfalciparumThe drug is also indicated for the treatment of extraintestinal amebiasis.
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as a consequence, distribution rather than elimination processes determine the blood concentration profile of chloroquine in patients with acute malaria.