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About 14of an intravenouslyor orally-administered dose of losartan is converted to its active metaboliteFollowing oral and intravenous administration of 14 C-labelled losartan potassiumcirculating plasma radioactivity primarily is attributed to losartan and its active metaboliteMinimal conversion of losartan to its active metabolite was seen in about one percent of individuals studied.
It is not recommended in children with glomerular filtration rate 2as no data are availablesee also section 4.4
Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patientsa lower dose should be considered for patients with a history of hepatic impairmentThere is no therapeutic experience with losartan in patients with severe hepatic impairmentTherefore losartan must not be administered in patients with severe hepatic impairmentsee sections 4.24.3 and 5.2
Read the Patient Information Leaflet if available from your pharmacist before you start taking losartan and each time you get a refillIf you have any questionsask your doctor or pharmacist.
Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin systemThereforethe use of losartan is not recommended.
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a patient with known hypersensitivity to aspirin and penicillin, when treated with cozaar, was withdrawn from study due to swelling of the lips and eyelids and facial rash, reported as angioedema, which returned to normal 5 days after therapy was discontinued.