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Reproduction studies have been performed in mice and rats at doses up to 11 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to cefadroxil monohydrateThere arehoweverno adequate and well controlled studies in pregnant womenBecause animal reproduction studies are not always predictive of human responsethis drug should be used during pregnancy only if clearly needed.
Prolonged use of DURICEFcefadroxilmay result in the overgrowth of honsusceptible organismsCareful observation of the patient is essentialIf superinfection occurs during therapyappropriate measures should be taken.
Caution should be exercised when cefadroxil monohydrate is administered to a nursing mother.
Note 1Susceptibility of staphylococci to cephalosporins is inferred from the methicillin susceptibility except for ceftazidime and cefixime and ceftibutenwhich do not have breakpoints and should not be used for staphylococcal infections.
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