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Co-administration with P-gp inhibitors and/or moderate or strong CYP3A4 inhibitors will increase the exposure to colchicinewhich may lead to colchicine induced toxicity including fatalitiesIf treatment with a P-gp inhibitor or a moderate or strong CYP3A4 inhibitor is required in patients with normal renal and hepatic functiona reduction in colchicine dosage or interruption of colchicine treatment is recommendedsee section 4.5

Toxic manifestations associated with colchicine include myelosuppressiondisseminated intravascular coagulationand injury to cells in the renalhepaticcirculatoryand central nervous systemThese most often occur with excessive accumulation or overdosagesee OVERDOSE

This Medication Guide summarizes the most important information about colchicine capsulesIf you would like more informationtalk to your pharmacist or healthcare provider for information about colchicine capsules that is written for health professionals.

Colchicine is contraindicated in patients with renal or hepatic impairment who are taking a P-gp inhibitore.gciclosporinverapamil or quinidineor a strong CYP3A4 inhibitore.gritonaviratazanavirindinavirclarithromycintelithromycinitraconazole or ketaconazolesee section 4.3

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cases of myopathy, including rhabdomyolysis, have been reported with hmg-coa reductase inhibitors, including rosuvastatin, coadministered with colchicine, and caution should be exercised when prescribing rosuvastatin with colchicine see drug interactions 7.