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Psychic derangements may appear when corticosteroids are usedranging from euphoriainsomniamood swingspersonality changesand severe depressionto frank psychotic manifestationsAlsoexisting emotional instability or psychotic tendencies may be aggravated by corticosteroids.
Ephedrine may enhance the metabolic clearance of corticosteroidsresulting in decreased blood levels and lessened physiologic activitythus requiring an increase in corticosteroid dosage.
If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivityclose observation is necessary as reactivation of the disease may occurDuring prolonged corticosteroid therapythese patients should receive chemoprophylaxis.
What is the mechanism of actionDexamethasone is referred to as a glucocorticoid or corticosteroidDexamethasone may produce anti-cancer effects through several speculated mechanismsOne such mechanism may be the inhibition of inflammatory agents in the bodywhich have been implicated in the development or growth of some cancers.
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