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CNS DepressantsPhenergan Tablets and Suppositories may increaseprolongor intensify the sedative action of other central-nervous-system depressantssuch as alcoholsedatives/hypnoticsincluding barbituratesnarcoticsnarcotic analgesicsgeneral anestheticstricyclic antidepressantsand tranquilizersthereforesuch agents should be avoided or administered in reduced dosage to patients receiving promethazine HClWhen given concomitantly with Phenergan Tablets and Suppositoriesthe dose of barbiturates should be reduced by at least one-halfand the dose of narcotics should be reduced by one-quarter to one-halfDosage must be individualizedExcessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with painthese symptoms usually disappear with adequate control of the pain.
CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING Phenergan TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDERIT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF Phenergan BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE AVOIDED.
Phenergan can cause side effects that may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be awake and alertAvoid drinking alcoholwhich can increase some of the side effects of PhenerganThere are many other medicines that can interact with promethazineTell your doctor about all the prescription and over-the-counter medications you useThis includes vitaminsmineralsherbal productsand drugs prescribed by other doctorsDo not start using a new medication without telling your doctorKeep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
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