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SMA is a genetic neurodegenerative disease that involves impairment of the neuromuscular transmissionSo Mestinonwhich facilitates the nerve signal transmission at the neuromuscular junctionNMJby inhibiting acetylcholine breakdowncould be a potential therapy for SMA.

It is an analog of Prostigminneostigminebut Mestinon is effective for a longer period of time and has fewer side effects on the digestive system.

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animal studies have shown that mestinon-sr pretreatment was effective only when animals were given atropine and 2-pam after exposure to soman.