Use birth control that you can trust to prevent pregnancy while taking hydrea and for 6 months after stopping this medicine.

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There are no data that support specific guidance for dosage adjustment in patients with hepatic impairmentClose monitoring of hematologic parameters is advised in these patients.

HYDREA may cause macrocytosiswhich is self-limitingand is often seen early in the course of treatmentThe morphologic change resembles pernicious anemiabut is not related to vitamin B12 or folic acid deficiencyThis may mask the diagnosis of pernicious anemiaProphylactic administration of folic acid is recommended.

Examples of drugs that can cause interactions with hydroxyurea are listed below.

Cutaneous vasculitic toxicitiesincluding vasculitic ulcerations and gangrenehave occurred in patients with myeloproliferative disorders during therapy with hydroxyureaThese vasculitic toxicities were reported most often in patients with a history ofor currently receivinginterferon therapyIf cutaneous vasculitic ulcers occurinstitute treatment and discontinue HYDREA.

Your red blood cells are responsible for carrying oxygen to the tissues in your bodyWhen the red cell count is lowyou may feel tired or weakYou should let your oncology care team know if you experience any shortness of breathdifficulty breathing or pain in your chestIf the count gets too lowyou may receive a blood transfusion.

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