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Perform a cardiovascular evaluation in triptan-naive patients who have multiple cardiovascular risk factorse.gincreased agediabeteshypertensionsmokingobesitystrong family history of CADprior to receiving Imitrex tabletsIf there is evidence of CAD or coronary artery vasospasmImitrex tablets are contraindicatedFor patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluationconsider administering the first dose of Imitrex tablets in a medically supervised setting and performing an electrocardiogramECGimmediately following administration of Imitrex tabletsFor such patientsconsider periodic cardiovascular evaluation in intermittent long-term users of Imitrex tablets.

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