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Maintenance dosage should range from 1 to 4 mg/kg bodyweight/day and must be adjusted according to clinical requirements and haematological tolerance.

Particular care should be taken to monitor haematological response and to reduce the maintenance dosage to the minimum required for clinical response.

A treatment regimen containing multiple immunosuppressantsincluding thiopurinesshould therefore be used with caution as this could lead to lymphoproliferative disorderssome with reported fatalitiesA combination of multiple immunosuppressantsgiven concomitantly increases the risk of Epstein-Barr virusEBVassociated lymphoproliferative disorders.

All drugs may cause side effectsHowevermany people have no side effects or only have minor side effectsCall your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

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