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There have been rare postmarketing reports of cognitive impairmente.gmemory lossforgetfulnessamnesiamemory impairmentconfusionassociated with statin useThese cognitive issues have been reported for all statinsThe reports are generally nonseriousand reversible upon statin discontinuationwith variable times to symptom onset1 day to yearsand symptom resolutionmedian of 3 weeks

Research has found that most side effects of statins are related to the dose patients takeThe higher the dosethe greater the risk of certain side effects.

The reductions in LDL-C from baseline were generally consistent across age groups within the trial as well as with previous experience in both adult and pediatric controlled trials.

Primary prevention of cardiovascular disease in individuals with no clinically evident heart disease but who are at risk because of combined effect of risk factors listed below.

A population pharmacokinetic analysis revealed no clinically relevant differences in pharmacokinetics among CaucasianHispanicand Black or Afro-Caribbean groupsHoweverpharmacokinetic studiesincluding one conducted in the UShave demonstrated an approximate 2fold elevation in median exposureAUC and Cmaxin Asian subjects when compared with a Caucasian control group.

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