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Careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking Keflex and metforminsee Clinical Pharmacology12.2
Advise patients that allergic reactionsincluding serious allergic reactionscould occur and that serious reactions require immediate treatmentAsk the patient about any previous hypersensitivity reactions to KEFLEXother beta-lactamsincluding cephalosporinsor other allergens Advise patients that diarrhea is a common problem caused by antibacterial drugs and usually resolves when the drug is discontinuedSometimesfrequent watery or bloody diarrhea may occur and may be a sign of a more serious intestinal infectionIf severe watery or bloody diarrhea developsadvise patients to contact their healthcare providerCounsel patients that antibacterial drugs including KEFLEXshould only be used to treat bacterial infectionsThey do not treat viral infectionse.gthe common coldWhen KEFLEX is prescribed to treat a bacterial infectiontell patients that although it is common to feel better early in the course of therapythe medication should be taken exactly as directedSkipping doses or not completing the full course of therapy may1decrease the effectiveness of the immediate treatment and2increase the likelihood that bacteria will develop resistance and will not be treatable by KEFLEX or other antibacterial drugs in the future.
In clinical trialsthe most frequent adverse reaction was diarrheaNausea and vomitingdyspepsiagastritisand abdominal pain have also occurredAs with penicillins and other cephalosporinstransient hepatitis and cholestatic jaundice have been reported.
Altered Laboratory TestsProlonged prothrombin timeincreased blood urea nitrogenBUNincreased creatinineelevated alkaline phosphataseelevated bilirubinelevated lactate dehydrogenaseLDHpancytopenialeukopeniaand agranulocytosis.
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