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One patienta 44 year-old male with MSdied in hospital on the second day following pump implantationAn autopsy demonstrated severe fibrosis of the coronary conduction systemA second patienta 52 year-old woman with MS and a history of an inferior wall myocardial infarctionwas found dead in bed 12 days after pump implantation2 hours after having had documented normal vital signsAn autopsy revealed pulmonary congestion and bilateral pleural effusionsIt is impossible to determine whether LIORESAL INTRATHECAL contributed to these deathsThe third patient underwent three baclofen screening trialsHis medical history included SCIaspiration pneumoniaseptic shockdisseminated intravascular coagulopathysevere metabolic acidosishepatic toxicityand status epilepticusTwelve days after screeninghe was not implantedhe again experienced status epilepticus with subsequent significant neurological deteriorationBased upon prior instructionextraordinary resuscitative measures were not pursued and the patient died.

It is mandatory that the patientall patient caregiversand the physicians responsible for the patient receive adequate information regarding the risks of this mode of treatmentAll medical personnel and caregivers should be instructed in 1the signs and symptoms of overdose2procedures to be followed in the event of overdose and 3proper home care of the pump and insertion site.

It is mandatory that the patientall patient caregiversand the physicians responsible for the patient receive adequate information regarding the risks of this mode of treatmentAll medical personnel and caregivers should be instructed in 1the signs and symptoms of overdose2procedures to be followed in the event of overdose and 3proper home care of the pump and insertion site.

Use this medication regularly to get the most benefit from itTo help you remembertake it at the same times each dayDo not stop taking this medication without consulting your doctorSome conditions may become worse when this drug is suddenly stoppedAlsoyou may experience withdrawal symptoms such as hallucinations and seizuresTo prevent withdrawal reactionsyour doctor may reduce your dose graduallyConsult your doctor or pharmacist for more detailsand report any withdrawal reactions right away.

Additional considerations pertaining to dosage adjustmentIt may be important to titrate the dose to maintain some degree of muscle tone and allow occasional spasms to1help support circulatory function2possibly prevent the formation of deep vein thrombosis3optimize activities of daily living and ease of care.

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