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If renal impairment existseven usual oral or parenteral doses may lead to excessive systemic accumulation of the drug and possible liver toxicityUnder such conditionslower than usual total doses are indicated andif therapy is prolongedserum level determinations of the drug may be advisableThis hazard is of particular importance in the parenteral administration of tetracyclines to pregnant or postpartum patients with pyelonephritisWhen used under these circumstancesthe blood level should not exceed 15 mcg/ml and liver function tests should be made at frequent intervalsOther potentially hepatotoxic drugs should not be prescribed concomitantly.
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Inclusion conjunctivitis may be treated with oral tetracyclines or with a combination of oral and topical agents.
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