Do not take this medicine with any of the following medications -cidofovir -methotrexate -other nsaids, medicines for pain and inflammation, like ibuprofen or naproxen -pemetrexed this medicine may also interact with the following medications -alcohol -aspirin and aspirin-like drugs -diuretics -fluconazole -lithium -medicines for high blood pressure -steroid medicines like prednisone or cortisone -warfarin.

Information about Methotrexate.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking methotrexate.
For the treatment of psoriasis or rheumatoid arthritistake this medication by mouth as directed by your doctorusually once a weekIt may take up to several months before you get the full benefit of this drug.
Methotrexate belongs to a class of drugs called antimetabolitesor folic acid antagonistsA class of drugs is a group of medications that work in a similar wayThese drugs are often used to treat similar conditions.
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methotrexate will be prescribed for you by a specialist doctor who is experienced in treating your condition.