Macrobid, generically known as nitrofurantoin, is an anti-infective used to treat or prevent infections of the urinary tract.
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Animal studies have shown that when nimodipine and zidovudine are administered concomitantlythe AUC for zidovudine was increasedand the volume of distribution and clearance rate decreasedThe clinical relevance of this interaction is unknownbut since the side-effect profile of zidovudine is known to be dose relatedthis interaction should be considered in patients receiving nimodipine and zidovudine concomitantly.
Avoid drinking alcohol while you are taking nimodipineAlcohol and nimodipine may cause low blood pressuredrowsinessor dizziness.
There are no adequate and well controlled studies in pregnant womenNo reproductive toxicology studies following parenteral administration are availableReproductive toxicology studies in animals after oral administration showed no teratogenic effectalthough studies in animals have shown reproductive toxicitysee section 5.3If Nimotop solution is to be administered during pregnancythe benefits and the potential risks mustthereforebe carefully weighed according to the severity of the clinical picture.
The medicine placed into a syringe should never be injected through a needle into the bodyor dangerously low blood pressure may resultNimodipine gel capsules are to be taken by mouth only.
Otherless serious side effects may be more likelyContinue taking nimodipine and talk to your doctor if you have any of these less serious side effects:
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antagonism has been demonstrated in vitro between nitrofurantoin and quinolone antimicrobial agents.