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As observed for angiotensin converting enzyme inhibitorslosartan and the other angiotensin antagonists are apparently less effective in lowering blood pressure in black people than in non-blackspossibly because of higher prevalence of low-renin states in the black hypertensive population.
When angiotensin II antagonists are administered simultaneously with NSAIDsi.eselective COX-2 inhibitorsacetylsalicylic acid at anti-inflammatory doses and non-selective NSAIDsattenuation of the antihypertensive effect may occurConcomitant use of angiotensin II antagonists or diuretics and NSAIDs may lead to an increased risk of worsening of renal functionincluding possible acute renal failureand an increase in serum potassiumespecially in patients with poor pre-existing renal functionThe combination should be administered with cautionespecially in the elderlyPatients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapyand periodically thereafter.
Losartan does not have an agonist effect nor does it block other hormone receptors or ion channels important in cardiovascular regulationFurthermore losartan does not inhibit ACEkininase IIthe enzyme that degrades bradykininConsequentlythere is no potentiation of undesirable bradykinin-mediated effects.
This drug may make you dizzyAlcohol or marijuana can make you more dizzyDo not driveuse machineryor do anything that needs alertness until you can do it safelyLimit alcoholic beveragesTalk to your doctor if you are using marijuana.
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