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Drugs such as gentamicintetracyclineranolazineRanexaverapamilCalanVerelanVerelan PMIsoptinIsoptin SRCovera-HSquinidineQuinagluteQuinideamiodaroneCordaroneindomethacinIndocinIndocin-SRalprazolamXanaxXanax XRNiravamspironolactoneAldactoneand itraconazoleSporanoxcan increase digoxin levels and the risk of toxicityThe co-administration of digoxin and beta-blockersfor example propranololInderalInderal LAor calcium channel blockers or CCBsfor exampleverapamilwhich also reduce heart ratecan cause serious heart rate slowingDiuretic-inducedfor exampleby furosemideLasixreduction in blood potassium or magnesium levels may predispose patients to digoxin-induced abnormal heart rhythmsSaquinavirInviraseand ritonavirNorvirincrease the amount of digoxin in the body and may cause digoxin toxicityMirabegronMybetriqincreases digoxin blood levelsThe lowest dose of digoxin should be used if by people who are also using mirabegronOmeprazolePrilosecand other drugs that reduce stomach acidity may increase blood levels of digoxin.
Since dizziness and blurred or yellow vision have been reportedyou should exercise caution before driving a vehicleusing machinery or participating in dangerous activities.
Nauseavomitingheadachedizzinessloss of appetiteand diarrhea may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.
In generalthe adverse reactions of LANOXIN are dose-dependent and occur at doses higher than those needed to achieve a therapeutic effectHenceadverse reactions are less common when LANOXIN is used within the recommended dose rangeis maintained within the therapeutic serum concentration rangeand when there is careful attention to concurrent medications and conditions.
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