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The daily dose must be individualized according to renal functionRefer to the following table and adjust the dose as indicatedTo use this dosing tablean estimate of the patient’s creatinine clearanceCLcrin ml/min is neededThe CLcr in ml/min may be estimated from serum creatininemg/dldetermination using the following formula:

Nervousness/Agitation Weight gain Headache Increased body movementHyperkinesiaFatigue/Sleepiness Nausea Depression Asthenia Feeling Weakness.

Exactly how this happens though is still a matter for debate and further scientific researchThere are a number of different ideas and hypotheses about specific methods.

Adjustment of the dose is recommended in elderly patients with compromised renal functionseeDosage adjustment in patients with renal impairmentbelowFor long term treatment in the elderlyregular evaluation of the creatinine clearance is required to allow dosage adaptation if needed.

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