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Anaphylactic reactions have been reporteddeath has also been reported in association with this eventPossible cross-sensitivity with other alkylating agents has been reportedSIADHsyndrome of inappropriate ADH secretionhas been reported with the use of cyclophosphamideMalaise and asthenia have been reported as part of the postmarketing experience.
AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.
Special attention to the possible development of toxicity should be exercised in patients being treated with cyclophosphamide if any of the following conditions are present.
Use of cyclophosphamide during pregnancy may affect the fetusFetuses exposed to cyclophosphamide may be born with missing fingerstoes and a poorly-developed heartCyclophosphamide should not be administered during pregnancyCyclophosphamide is excreted in breast milk and could cause serious problems in the nursing infant.
The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital.
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