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Cyclophosphamide is excreted in breast milkBecause of the potential for serious adverse reactions and the potential for tumorigenicity shown for cyclophosphamide in humansa decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the importance of the drug to the mother.
Hemorrhagic cystitis may develop in patients treated with cyclophosphamideRarelythis condition can be severe and even fatalFibrosis of the urinary bladdersometimes extensivealso may develop with or without accompanying cystitisAtypical urinary bladder epithelial cells may appear in the urineThese adverse effects appear to depend on the dose of cyclophosphamide and the duration of therapySuch bladder injury is thought to be due to cyclophosphamide metabolites excreted in the urineForced fluid intake helps to assure an ample output of urinenecessitates frequent voidingand reduces the time the drug remains in the bladderThis helps to prevent cystitisHematuria usually resolves in a few days after cyclophosphamide treatment is stoppedbut it may persistMedical and/or surgical supportive treatment may be requiredrarelyto treat protracted cases of severe hemorrhagic cystitisIt is usually necessary to discontinue cyclophosphamide therapy in instances of severe hemorrhagic cystitis.
Hemorrhagic cystitis may develop in patients treated with cyclophosphamideRarelythis condition can be severe and even fatalFibrosis of the urinary bladdersometimes extensivealso may develop with or without accompanying cystitisAtypical urinary bladder epithelial cells may appear in the urineThese adverse effects appear to depend on the dose of cyclophosphamide and the duration of therapySuch bladder injury is thought to be due to cyclophosphamide metabolites excreted in the urineForced fluid intake helps to assure an ample output of urinenecessitates frequent voidingand reduces the time the drug remains in the bladderThis helps to prevent cystitisHematuria usually resolves in a few days after cyclophosphamide treatment is stoppedbut it may persistMedical and/or surgical supportive treatment may be requiredrarelyto treat protracted cases of severe hemorrhagic cystitisIt is usually necessary to discontinue cyclophosphamide therapy in instances of severe hemorrhagic cystitis.
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