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The available data in subjects with moderate renal insufficiency are scarce and no reliable estimation of the systemic exposure to metformin in this subgroup as compared to subjects with normal renal function could be madeThereforethe dose adaptation should be made upon clinical efficacy/tolerability considerationssee section 4.2
It may be harder to control your blood sugar when your body is stressedsuch as due to feverinfectioninjuryor surgeryConsult your doctor because increased stress may require a change in your treatment planmedicationsor blood sugar testing.
Controlled clinical studies of metformin did not include sufficient numbers of elderly patients to determine whether they respond differently from younger patients.
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