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When these medications are administered to or withdrawn from a patient receiving repaglinidethe patient should be observed closely for changes in glycaemic control.

The blood glucose-lowering effect of oral hypoglycaemic medicinal products decreases in many patients over timeThis may be due to progression of the severity of the diabetes or to diminished responsiveness to the medicinal productThis phenomenon is known as secondary failureto distinguish it from primary failurewhere the medicinal product is ineffective in an individual patient when first givenAdjustment of dose and adherence to diet and exercise should be assessed before classifying a patient as a secondary failure.

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