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The following symptomsanxietyagitationpanic attacksinsomniairritabilityhostilityaggressivenessimpulsivityakathisiapsychomotor restlessnesshypomaniaand maniahave been reported in adult and pediatric patients being treated with antidepressants for Major Depressive Disorder as well as for other indicationsboth psychiatric and nonpsychiatricAlthough a causal link between the emergence of such symptoms and either the worsening of depression and/or the emergence of suicidal impulses has not been establishedthere is concern that such symptoms may represent precursors to emerging suicidality.

During pregnancythis medication should be used only when clearly neededIt may harm an unborn babyAlsobabies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficultiesseizuresmuscle stiffnessor constant cryingIf you notice any of these symptoms in your newborntell the doctor promptly.

If you have diabetesfluoxetine may affect your blood sugar levelsMonitor your blood sugar regularly and share the results with your doctorYour doctor may need to adjust your medicationdietand exercise when you start or stop fluoxetine.

Some products that may interact with this drug includedrugs removed from your body by certain liver enzymes including vinblastineantiarrhythmics such as propafenone/flecainidetricyclic antidepressants such as desipramine/imipramineother drugs that can cause bleeding/bruising including antiplatelet drugs such as clopidogrelNSAIDs such as ibuprofenblood thinnerssuch as warfarin.

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