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If clinical hepatitis occurscharacterised by anorexianauseavomitingicterus AND laboratory findingssuch as moderate or severe liver function test abnormalitiesexcluding GGTnevirapine must be permanently stoppedViramune must not be readministered to patients who have required permanent discontinuation for clinical hepatitis due to nevirapine.

Viramune should be administered by physicians who are experienced in the treatment of HIV infection.

Any patient experiencing severe rash or a rash accompanied by constitutional symptoms such as feverblisteringoral lesionsconjunctivitisfacial oedemamuscle or joint achesor general malaise should discontinue the medicinal product and immediately seek medical evaluationIn these patients nevirapine must not be restarted.

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