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The following side effects have been reported by at least 1of people taking this medicationMany of these side effects can be managedand some may go away on their own over time.

Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic diseaseexcept leukemiain the presence of ZyloprimHoweverin a well-controlled study of patients with lymphoma on combination therapyZyloprim did not increase the marrow toxicity of patients treated with cyclophosphamidedoxorubicinbleomycinprocarbazineand/or mechlorethamine.

Allopurinol can decrease the number of blood cells in your body that make blood clot and that help you fight infectionswhich can make it easier for you to bleed from an injury or get sick when exposed to others who are illYou should avoid being around people who are sick or have infections while taking this medicine.

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zyloprim allopurinol should be discontinued at the first appearance of skin rash or other signs which may indicate an allergic reaction.