Two metabolites are active, with one metabolite appearing to account for at least 50 of the pharmacologic pde iii inhibition activity after administration of pletal.
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Pletal is a prescription medicine used to reduce the symptoms of intermittent claudication and can increase your ability to walk further distances.
The effect of CYP3A4 and CYP2C19 inducerssuch as carbamazepinephenytoinrifampicin and StJohn’s worton cilostazol pharmacokinetics has not been evaluatedThe antiplatelet effect may theoretically be altered and should be carefully monitored when cilostazol is co-administered with CYP3A4 and CYP2C19 inducers.
Administration of cilostazol with diltiazema weak inhibitor of CYP3A4resulted in an increase in the AUC of cilostazol of 44accompanied by a 4increase in AUC of the dehydro metabolite and a 43increase in the AUC of the 4trans-hydroxy metabolite.
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adverse reactions were assessed in eight placebo-controlled clinical trials involving patients exposed to either 50 or 100 mg twice daily pletal n 1301 or placebo n 973 , with a median treatment duration of 127 days for patients on pletal and 134 days for patients on placebo.