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This medicine may raise the chance of heart and blood vessel side effects like heart attack and strokeIf these happenthey can be deadlyThe risk of these side effects may be greater if you have heart disease or risks for heart diseaseHoweverthe risk may also be raised in people who do not have heart disease or risks for heart diseaseThe risk of these health problems can happen as soon as the first weeks of using Ponstelmefenamic acidand may be greater with higher doses or with long-term useDo not use Ponstelmefenamic acidright before or after bypass heart surgeryThis medicine may raise the chance of very bad and sometimes deadly stomach or bowel side effects like ulcers or bleedingThe risk is greater in older peopleThe risk is also greater in people who have had stomach or bowel ulcers or bleeding beforeThese problems may occur without warning signsTalk with the doctor.

The pharmacological activity of Ponstel in reducing inflammationand possibly fevermay diminish the utility of diagnostic signs in detecting infections.

This medication may make you more sensitive to the sunLimit your time in the sunAvoid tanning booths and sunlampsUse sunscreen and wear protective clothing when outdoorsTell your doctor right away if you get sunburned or have skin blisters/redness.

Strategies to Minimize the GI Risks in NSAID-treated patients Use the lowest effective dosage for the shortest possible durationAvoid administration of more than one NSAID at a timeAvoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleedingFor such patientsas well as those with active GI bleedingconsider alternate therapies other than NSAIDsRemain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapyIf a serious GI adverse event is suspectedpromptly initiate evaluation and treatmentand discontinue Ponstel until a serious GI adverse event is ruled outIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxismonitor patients more closely for evidence of GI bleedingsee PRECAUTIONSDrug Interactions

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