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Pharmacodynamics Diuretic actionLoop diuretics inhibit sodium and chloride reabsorption in the proximal part of the ascending loop of Henlepromoting the excretion of sodiumwaterchlorideand potassiumAntihypertensive actionThis drug effect may be the result of renal and peripheral vasodilatation and a temporary increase in glomerular filtration rate and a decrease in peripheral vascular resistance.
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