The combination of clopidogrel with nonsteroidal anti-inflammatory drugs nsaids such as ibuprofen motrin, advil, nuprin , naproxen naprosyn, aleve , diclofenac voltaren , etodolac lodine , nabumetone relafen , fenoprofen nalfon , flurbiprofen ansaid , indomethacin indocin , ketoprofen orudis; oruvail , oxaprozin daypro , piroxicam feldene , sulindac clinoril , tolmetin tolectin , and mefenamic acid ponstel may increase the risk of stomach and intestinal bleeding.

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Undesirable effects such as dizzinessdrowsinessfatigue and visual disturbances are possible after taking NSAIDsIf affectedpatients should not drive or operate machinery.

AnticoagulantsNSAIDsincluding piroxicammay enhance the effects of anticoagulantssuch as warfarinTherefore the use of piroxicam with concomitant anticoagulant such as warfarin should be avoidedsee section 4.3

If you switch brands of piroxicamyour dose needs may changeFollow your doctor’s instructions about how much medicine to take.

Before taking piroxicamtell your doctor if you are taking any of the following drugs:

Symptoms following acute NSAID overdoses have been typically limited to lethargydrowsinessnauseavomitingand epigastric painwhich are generally reversible with supportive careGastrointestinal bleeding has occurredHypertensionacute renal failurerespiratory depressionand coma have occurredbut were raresee WARNINGS AND PRECAUTIONS

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