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Prograf can harm your kidneysand this effect is increased when you also use certain other medicines harmful to the kidneysBefore using Prograftell your doctor about all other medicines you useMany other drugsincluding some over-the-counter medicinescan be harmful to the kidneys.
Use with sirolimus is not recommended in liver and heart transplantThe safety and efficacy of Prograf with sirolimus has not been established in kidney transplantsee WARNINGS AND PRECAUTIONS
Dosing should be titrated based on clinical assessments of rejection and tolerabilityLower Prograf dosages than the recommended initial dosage may be sufficient as maintenance therapyAdjunct therapy with adrenal corticosteroids is recommended early post-transplant.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongationBefore using tacrolimustell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death
Tacrolimus may cause diabetesTell your doctor or pharmacist if you experience any of the following symptoms of high blood sugarincreased thirst/hungerfrequent urination.
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