Administration of cardizem with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20 .
Information about Cardizem.
Diltiazem may be only part of a complete program of treatment that also includes dietexerciseand other medicationsFollow your dietmedicationand exercise routines very closely.
Diltiazem is an inhibitor of CYP3A4 and has been shown to increase significantly the AUC of some statinsThe risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4 may be increased with concomitant use of diltiazemWhen possibleuse a non-CYP3A4-metabolized statin together with diltiazemotherwisedose adjustments for both diltiazem and the statin should be considered along with close monitoring for signs and symptoms of any statin related adverse events.
The following postmarketing events have been reported infrequently in patients receiving CARDIZEMacute generalized exanthematous pustulosisallergic reactionsalopeciaangioedemaincluding facial or periorbital edemaasystoleerythema multiformeincluding Stevens-Johnson syndrometoxic epidermal necrolysisextrapyramidal symptomsgingival hyperplasiahemolytic anemiaincreased bleeding timeleukopeniaphotosensitivityincluding lichenoid keratosis and hyperpigmentation at sun-exposed skin areaspurpuraretinopathymyopathyand thrombocytopeniaThere have been observed cases of a generalized rashsome characterized as leukocytoclastic vasculitisIn additionevents such as myocardial infarction have been observedwhich are not readily distinguishable from the natural history of the disease in these patientsA definitive cause and effect relationship between these events and CARDIZEM therapy cannot yet be establishedExfoliative dermatitisproven by rechallengehas also been reported.
Although precise mechanisms of its antianginal action are still being delineatedCARDIZEM is believed to act in the following ways:
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cardizem, which garnered the largest percentage of net sales–47 percent in 1986–slowed calcium buildup, preventing the artery muscles from being blocked by calcium deposits.