Clozapine clozaril has also been in use accustomed to recompense treatment-resistant cases with some triumph but requires sign monitoring owing to the hidden side influence of agranulocytosis.

Information about Clozaril.

Treatment resistance is defined as a lack of satisfactory clinical improvement despite the use of adequate doses of at least two different antipsychotic agentsincluding an atypical antipsychotic agentprescribed for adequate duration.

In the event of planned termination of Clozaril therapya gradual reduction in dose over a 1 to 2-week period is recommendedIf abrupt discontinuation is necessarythe patient should be carefully observed for the occurrence of withdrawal reactionssee section 4.4

Clozaril is indicated in treatment-resistant schizophrenic patients and in schizophrenia patients who have severeuntreatable neurological adverse reactions to other antipsychotic agentsincluding atypical antipsychotics.

Prescribing physicians must comply fully with the required safety measuresAt each consultationa patient receiving Clozaril must be reminded to contact the treating physician immediately if any kind of infection begins to developParticular attention must be paid to flu-like complaints such as fever or sore throat and to other evidence of infectionwhich may be indicative of neutropeniasee section 4.4

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clozaril is an atypical antipsycotic.