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Patients should be monitored for withdrawal symptoms when discontinuing treatment with trazodone hydrochlorideThe dose should be gradually reduced whenever possible.

In humansDesyrel is well absorbed after oral administration without selective localization in any tissueWhen Desyrel is taken shortly after ingestion of foodthere may be an increase in the amount of drug absorbeda decrease in maximum concentration and a lengthening in the time to maximum concentrationPeak plasma levels occur approximately one hour after dosing when Desyrel is taken on an empty stomach or two hours after dosing when taken with food.

In vitro drug metabolism studies suggest that there is a potential for drug interactions when trazodone is given with CYP3A4 inhibitorsRitonavira potent CYP3A4 inhibitorincreased the C maxAUCand elimination half-lifeand decreased clearance of trazodone after administration of ritonavir twice daily for 2 daysAdverse effects including nauseahypotensionand syncope were observed when ritonavir and trazodone were co-administeredIt is likely that ketoconazoleindinavirand other CYP3A4 inhibitors such as itraconazole or nefazodone may lead to substantial increases in trazodone plasma concentrationswith the potential for adverse effectsIf trazodone is used with a potent CYP3A4 inhibitora lower dose of trazodone should be considered.

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for more information about antidepressants containing active ingredient trazodone, please, read the faq on desyrel.