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MISSED DOSEFor the best possible benefitit is important to take each scheduled dose of this medication as directedIf you miss a dosetake it as soon as you rememberIf it is near the time of the next doseskip the missed dose and resume your usual dosing scheduleDo not double the dose to catch up.

Tell your doctor right away if any of these rare but seriousvision changessuch as blurred/decreased/double visioncolor blindnesseye painnumbness/tingling of arms/legs.

If you have diabetesthis product may lower your blood sugarCheck your blood sugar regularly as directed and share the results with your doctorTell your doctor right away if you have symptoms of low blood sugarsuch as sudden sweatingshakingfast heartbeathungerblurred visiondizzinessor tingling hands/feetYour doctor may need to adjust your diabetes medicationexercise programor diet.

Ethionamide may be bacteriostatic or bactericidal in actiondepending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organismEthionamidelike prothionamide and pyrazinamideis a nicotinic acid derivative related to isoniazidIt is thought that ethionamide undergoes intracellular modification and acts in a similar fashion to isoniazidIsoniazid inhibits the synthesis of mycoloic acidsan essential component of the bacterial cell wallSpecifically isoniazid inhibits InhAthe enoyl reductase from Mycobacterium tuberculosisby forming a covalent adduct with the NAD cofactorIt is the INH-NAD adduct that acts as a slowtight-binding competitive inhibitor of InhA.

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among the second-line drugs, ethionamide, protionamide, and pas can be hepatotoxic, although to a lesser extent than the first-line drugs.