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HYDREA may damage spermatozoa and testicular tissueresulting in possible genetic abnormalitiesMales with female sexual partners of reproductive potential should use effective contraception during and after treatment with HYDREA for at least 1 year after therapysee Nonclinical Toxicology
DroxiaThe typical initial dosage is 15 mg per kilogram of body weighttaken once per dayHydrea and generic hydroxyureaThese forms are not used for this condition.
Bone marrow suppressiondrop in white blood cellred blood cell and platelet countsanorexianauseavomitingdiarrheaconstipationsores in the mouthskin rashswelling in the handsfeetlegs and facechanges in skin pigmentationhair losspainful urinationdrowsinessheadachedizzinessdisorientationhallucinationsseizuresliver problemsshortness of breathmetabolic disturbancesand kidney problems.
There are no data that support specific guidance for dosage adjustment in patients with hepatic impairmentClose monitoring of hematologic parameters is advised in these patients.
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